Question 1

Retroviruses are characterized by the presence of ________ that flank the viral structural genes.

Accepted Answer

long termi...

Question 2

The only function of Uracil-DNA N-glycosylase is to remove dUMP residues in DNA that have been arisen by deamination of cytosine.

Accepted Answer

A) True 
 B)False

Question 3

The dam methylase has a role in which of the following DNA repair systems?

Accepted Answer

A)   Base-excision repair
B)   Nucleotide excision repair
C)   Non-homologous end-joining
D)   Mismatch repair
E)   Homologous recombinationF) B) and C)
G) A) and E)

Question 4

Nucleotide excision repair:

Accepted Answer

A)   involves a multisubunit enzyme.
B)   preferentially repairs genes that are being actively transcribed.
C)   involves making nicks on either side of a DNA lesion.
D)   uses helicase, polymerase and ligase to repair the DNA.
E)   all of the above.F) C) and D)
G) B) and E)

Question 5

Base excision repair starts with cleavage of the ________ between the damaged base and the deoxyribose.

Accepted Answer

The answer of Base excision repair starts with cleavage of...

Question 6

The movement of transposable genetic elements within a genome is essentially ________.

Accepted Answer

random

Question 7

Site-specific recombination generally requires longer homologous sequences than does homologous recombination.

Accepted Answer

A) True 
 B)False

Question 8

________ and bulky adducts on DNA can be repaired using the nucleotide excision repair process.

Accepted Answer

The answer of ________ and bulky adducts on DNA can...

Question 9

The SOS response to DNA damage in bacteria is error-prone because:

Accepted Answer

A)   it uses DNA polymerase that lacks 5' exonuclease activity.
B)   it is an inducible system.
C)   the polymerases used lack 3' exonuclease activity.
D)   more than one polymerase can be used to repair the damage.
E)   it is stimulated by ultraviolet light that causes mutations.F) A) and C)
G) All of the above

Question 10

Bacteria cannot use homologous recombination for DNA repair as they only have a single copy of their genome.

Accepted Answer

A) True 
 B)False  False

Question 11

Which of the following enzyme activities is NOT used in base excision repair?

Accepted Answer

A)   Glycosylase
B)   Apyriminidic endonuclease
C)   Deoxyribose-5'-phosphatase
D)   DNA polymerase
E)   HelicaseF) C) and D)
G) All of the above

Question 12

One mechanism that could result in gene duplication involves ________ sister-chromatid exchange.

Accepted Answer

The answer of One mechanism that could result in gene...

Question 13

Strand-displacement in homologous recombination in E. coli is facilitated by:

Accepted Answer

A)   the RecBCD complex.
B)   ss-binding protein.
C)   RecA.
D)   RuvC.
E)   the chi structure.F) A) and B)
G) A) and C)

Question 14

Which of the following mechanisms is NOT involved in the generation of antibody diversity?

Accepted Answer

A)   Recombination with excision of DNA between a V gene sequence and a J sequence
B)   Splicing out of RNA sequences between a J region and a C region
C)   Somatic hypermutation
D)   Non-homologous end joining and DNA repair
E)   TranspositionF) B) and E)
G) C) and D)

Question 15

Which of the following types of DNA damage cannot be repaired by base excision repair?

Accepted Answer

A)   Depurination
B)   Cytosine deamination
C)   Thymine dimer
D)   Single-strand break
E)   Base oxidationF) A) and B)
G) D) and E)

Question 16

The direct DNA repair enzymes DNA photolyase and O6-alkyguanine alkytransferase are unusual in that they are ________ after one catalytic cycle.

Accepted Answer

The answer of The direct DNA repair enzymes DNA photolyase...

Question 17

The λ genome is inserted into the E. coli genome in the lysogenic pathway by the use of ________ recombination.

Accepted Answer

The answer of The λ genome is inserted into the...

Question 18

O6-methylguanine has a high probability of base pairing with thymine to result in a post replication mutation from a GC base pair to:

Accepted Answer

A)   TA.
B)   AT.
C)   CG.
D)   GT.
E)   TC.F) A) and D)
G) B) and E) B

Question 19

Photoreactivation using DNA photolyase is responsible for direct repair of thymine dimers in all organisms.

Accepted Answer

A) True 
 B)False

Question 20

Transcription-coupled repair usually repairs the template strand.

Accepted Answer

A) True 
 B)False

Exam 23: DNA Repair, Recombination, and Rearrangement

Retroviruses are characterized by the presence of ________ that flank the viral structural genes.

Correct Answerverifiedlong termi...View AnswerShow Answer

The only function of Uracil-DNA N-glycosylase is to remove dUMP residues in DNA that have been arisen by deamination of cytosine.

Correct AnswerverifiedShow Answer

The dam methylase has a role in which of the following DNA repair systems?

Correct AnswerverifiedShow Answer

Nucleotide excision repair:

Correct AnswerverifiedShow Answer

Base excision repair starts with cleavage of the ________ between the damaged base and the deoxyribose.

Correct AnswerverifiedShow Answer

The movement of transposable genetic elements within a genome is essentially ________.

Correct Answerverifiedrandom

Site-specific recombination generally requires longer homologous sequences than does homologous recombination.

Correct AnswerverifiedShow Answer

________ and bulky adducts on DNA can be repaired using the nucleotide excision repair process.

Correct AnswerverifiedShow Answer

The SOS response to DNA damage in bacteria is error-prone because:

Correct AnswerverifiedShow Answer

Bacteria cannot use homologous recombination for DNA repair as they only have a single copy of their genome.

Correct AnswerverifiedFalse

Which of the following enzyme activities is NOT used in base excision repair?

Correct AnswerverifiedShow Answer

One mechanism that could result in gene duplication involves ________ sister-chromatid exchange.

Correct AnswerverifiedShow Answer

Strand-displacement in homologous recombination in E. coli is facilitated by:

Correct AnswerverifiedShow Answer

Which of the following mechanisms is NOT involved in the generation of antibody diversity?

Correct AnswerverifiedShow Answer

Which of the following types of DNA damage cannot be repaired by base excision repair?

Correct AnswerverifiedShow Answer

The direct DNA repair enzymes DNA photolyase and O6-alkyguanine alkytransferase are unusual in that they are ________ after one catalytic cycle.

Correct AnswerverifiedShow Answer

The λ genome is inserted into the E. coli genome in the lysogenic pathway by the use of ________ recombination.

Correct AnswerverifiedShow Answer

O6-methylguanine has a high probability of base pairing with thymine to result in a post replication mutation from a GC base pair to:

Correct AnswerverifiedB

Photoreactivation using DNA photolyase is responsible for direct repair of thymine dimers in all organisms.

Correct AnswerverifiedShow Answer

Transcription-coupled repair usually repairs the template strand.

Correct AnswerverifiedShow Answer

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random

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False

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B

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