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The first signal during helper T-lymphocyte activation involves


A) BCR of the helper T-cell binding with free antigen and engulfing it.
B) CD8 of the helper T-cell binding with MHC class III of the antigen-presenting cell.
C) CD4 of the helper T-cell binding with MHC class I part of the antigen fragment.
D) CD4 of the helper T-cell binding with MHC class II of the antigen-presenting cell.

E) All of the above
F) A) and D)

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If someone had a cut in their skin through which a bacterium entered,but that bacterium was then destroyed by a neutrophil,this would be an example of


A) failed external adaptive immunity,but successful innate immunity.
B) failed innate immunity,but successful adaptive immunity.
C) failed external innate immunity,but successful internal innate immunity.
D) failed external immunity,but successful internal acquired immunity.

E) C) and D)
F) A) and B)

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Which type of lymphocyte has coreceptors that assist in the interaction of the lymphocyte with a cell presenting antigen


A) T-lymphocyte
B) B-lymphocyte

C) A) and B)
D) undefined

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Which of the following lists the body's first,second,and third lines of defense in order


A) Adaptive immunity,external innate immunity,internal immunity
B) External innate immunity,internal innate immunity,adaptive immunity
C) External innate immunity,adaptive immunity,internal innate immunity
D) External adaptive immunity,internal adaptive immunity,innate immunity
E) Innate immunity,internal adaptive immunity,internal innate immunity

F) C) and D)
G) B) and D)

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What are the five main classes of immunoglobulins found in humans


A) IgA,IgC,IgE,IgG,IgI
B) IgD,IgE,IgG,IgM,IgS
C) IgB,IgD,IgE,IgG,IgM
D) IgA,IgB,IgC,IgD,IgE
E) IgA,IgD,IgE,IgG,IgM

F) A) and B)
G) B) and E)

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Which type of cell attacks a variety of unwanted cells and causes those cells to undergo apoptosis


A) Natural killer cells
B) Basophils
C) Neutrophils
D) Eosinophils
E) Macrophages

F) C) and E)
G) A) and B)

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When they leave the red marrow,pre-T-lymphocytes have


A) only the CD4 protein.
B) only the CD8 protein.
C) both the CD4 and CD8 proteins.
D) neither the CD4 nor CD8 protein.
E) either the CD4 or CD8 protein.

F) A) and C)
G) A) and E)

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Interleukin 1 and interferons act as


A) defervescents and trigger an elevation of body temperature.
B) defervescents and trigger a decrease of body temperature.
C) pyrogens and trigger an elevation of body temperature.
D) pyrogens and trigger a decrease of body temperature.

E) B) and C)
F) A) and B)

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The secondary response of the immune system to an infectious agent involves


A) fewer cells than the antigen challenge,as the response has become more specific.
B) more cells than the antigen challenge,due to the proliferation of memory cells.
C) amnesia of past exposures,so that a perfectly adapted response can be generated to the new pathogen.

D) All of the above
E) A) and B)

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Antigen presentation involves the display of an antigen


A) inside the cytoplasm of a B-lymphocyte.
B) on the surface of a cell so that a B-lymphocyte can be exposed to it.
C) inside the cytoplasm of a T-lymphocyte.
D) on the surface of a cell so that a T-lymphocyte can be exposed to it.

E) B) and C)
F) A) and B)

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Pyrogens act on the __________ of the brain where they cause release of ________.


A) hippocampus;PGE2
B) hippocampus;exudate
C) hypothalamus;PGE2
D) hypothalamus;exudate

E) B) and C)
F) A) and D)

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Cytokines are agents that affect neighboring cells without triggering systemic effects.

A) True
B) False

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MHC class II molecules are loaded with exogenous antigen after the antigen has been digested into fragments within a phagolysosome.

A) True
B) False

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Defensins and lysosomes are both part of ________ immunity and function as ___________.


A) adaptive;physical barriers to pathogen entry
B) adaptive;attackers of pathogenic cells
C) innate;physical barriers to pathogen entry
D) innate;attackers of pathogenic cells

E) None of the above
F) C) and D)

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Compared to most interstitial fluid in the body,the interstitial fluid of an inflamed area would have a lower osmolarity and a lower concentration of proteins.

A) True
B) False

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Proteins known as _______ are produced by a variety of cells;they increase capillary permeability,increase CAM production in the endothelium,and stimulate pain receptors.

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A virus is ______ than a bacterial cell,and a virus is composed of a _________________.


A) larger;nucleic acid within a protein capsid.
B) larger;eukaryotic cell with a cell wall.
C) smaller;nucleic acid within a protein capsid.
D) smaller;eukaryotic cell with a cell wall.

E) B) and C)
F) A) and B)

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Poison ivy contains a toxin that acts as a hapten by


A) raising the body's sensitivity to a wide variety of chemicals such as penicillin.
B) cutting plasma protein antibodies in half.
C) preventing effective immune responses by blocking release of bradykinin.
D) combining with a body protein and then triggering an immune response.

E) B) and D)
F) A) and C)

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Which class of major histocompatibility molecules is specific to antigen-presenting cells


A) MHC class I
B) MHC class II

C) A) and B)
D) undefined

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Which type of cell is the most effective to attack multicellular parasites such as tapeworms


A) Basophils
B) Eosinophils
C) Macrophages
D) Neutrophils

E) A) and B)
F) A) and C)

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