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When certain sedative-hypnotics are suddenly discontinued,sleep disturbances may actually increase.This situation is known commonly as


A) tardive dyskinesia
B) anterograde amnesia
C) rebound insomnia
D) malignant hyperthermia
E) none of the above are true

F) B) and D)
G) A) and D)

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C

When used to treat anxiety disorders,buspirone (BuSpar) acts by increasing the effects of _________ in certain areas of the brain,whereas more traditional antianxiety drugs such as Valium increase the inhibitory effects of _______ in the CNS.


A) GABA; serotonin
B) serotonin; GABA
C) GABA; acetylcholine
D) acetylcholine; serotonin
E) serotonin; dopamine

F) A) and B)
G) All of the above

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B

In addition to traditional sedatives like the benzodiazepines (e.g.,diazepam [Valium]) ,all of the following drug strategies can produce sedation EXCEPT


A) antihistamines
B) amphetamines
C) certain antidepressants
D) certain antipsychotics
E) opioids

F) A) and B)
G) A) and C)

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Drugs used to relax the patient and promote sleep are classified as


A) sedative-hypnotics
B) antidepressants
C) antipsychotics
D) neuroleptics
E) antidyskinetics

F) B) and E)
G) D) and E)

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Antidepressants such as paroxetine or venlafaxine can also be used to treat anxiety because


A) they may be an effective substitute for people who cannot tolerate the side effects of traditional antianxiety drugs
B) they may resolve certain cases of anxiety with less chance of addiction
C) many patients with anxiety also have symptoms of depression
D) all of the above are true
E) none of the above are true

F) A) and D)
G) None of the above

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Problems such as a "hang-over" effect and other residual symptoms that occur the morning after a person takes a sedative-hypnotic can often be resolved by


A) lowering the dose of the sedative-hypnotic
B) switching to a drug that has a shorter half-life
C) switching to one of the newer agents (zolpidem, zalepon) that tend to have milder residual effects
D) all the above are true
E) none of the above are true

F) A) and B)
G) C) and D)

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Benzodiazepines such as diazepam (Valium) act by increasing the inhibitory effects of the neurotransmitter


A) acetylcholine
B) norepinephrine
C) dopamine
D) gamma-aminobutyric acid (GABA)
E) 5-hydroxytryptamine (serotonin)

F) A) and B)
G) A) and C)

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D

Diazepam (Valium) and other benzodiazepines bind to specific GABA receptors in the CNS,and inhibit neuronal activity by _____ the conductance of ______ ions into the neuron.


A) increasing; sodium
B) decreasing; sodium
C) increasing; potassium
D) decreasing; potassium
E) increasing; chloride

F) A) and B)
G) B) and D)

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