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The structural features common to all antibody classes are


A) two pairs of a heavy chain and a light chain which form an antigen binding site.
B) a stem formed of a light chain and a heavy chain.
C) an antigen binding site formed by two light chains.
D) an antigen binding site formed by a single heavy chain.
E) a heavy chain paired with a light chain.

F) None of the above
G) All of the above

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Vaccination triggers an immune response which produces immunity.


A) natural passive
B) artificial active
C) artificial passive
D) natural active
E) both active and passive

F) B) and C)
G) A) and B)

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The epitope specificity of a T lymphocyte is determined by its (MHC/BCR/TCR).

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A variety of molecular components of the adaptive immune system bind epitopes (antigenic determinants). Compare and contrast the binding of epitopes by antibody molecules, T cell receptors (TCRs), and MHC molecules, and describe the consequences of the different interactions.

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Antibody molecules produced by B lymphoc...

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The protozoan that causes malaria is an intracellular parasite of red blood cells (RBCs) . An adaptive immune response to this parasite is problematic because


A) RBCs never enter lymphoid tissue.
B) RBCs normally produce cytokines necessary for adaptive immune response, which this infection prevents.
C) complement cannot effectively destroy RBCs.
D) red blood cells do not produce MHC and therefore do not display the fact that they have been infected by presenting antigen.
E) the parasite damages leukocytes along with RBCs.

F) C) and D)
G) B) and E)

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D

Each B lymphocyte develops a unique BCR variable region by random assembly of immunoglobulin gene fragments.

A) True
B) False

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Secretory IgA antibodies are unique because they


A) have unique light chains.
B) are present in the plasma.
C) are present in lymph nodes.
D) are Y-shaped molecules.
E) are connected with J chains and short polypeptides to form dimers.

F) None of the above
G) B) and D)

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Which of the following best describes IgM antibodies?


A) They cause basophils and eosinophils to degranulate.
B) They interact with phagocytes and NK cells.
C) They can cross the placenta to provide passive immunity.
D) They are the most common type of antibody in the blood during the initial phases of an immune response.
E) They are the antibody class found in body secretions.

F) D) and E)
G) B) and C)

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D

  The type of immunoglobulin illustrated here is A)  IgM. B)  IgD. C)  IgA. D)  IgE. E)  IgG. The type of immunoglobulin illustrated here is


A) IgM.
B) IgD.
C) IgA.
D) IgE.
E) IgG.

F) A) and B)
G) A) and C)

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Compare and contrast clonal deletion and clonal selection of B lymphocytes.

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Both clonal deletion and clonal selectio...

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Which of the following cytokines act as a signal between leukocytes?


A) chemokines
B) growth factors
C) interleukins
D) tumor necrosis factors
E) interferons

F) B) and D)
G) D) and E)

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Large accumulations of unactivated self-tolerant lymphocytes conducting surveillance for specific antigenic determinants are found in


A) lymph nodes.
B) the MALT.
C) the thymus.
D) the MALT and lymph nodes.
E) the MALT, lymph nodes, and thymus.

F) C) and D)
G) All of the above

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Which of the following recognizes and binds to MHC II antigens and helps stabilize the binding of epitopes to T cell receptors?


A) CD26
B) CD4
C) CCR5
D) MHC I
E) CCR3

F) B) and D)
G) All of the above

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Professional antigen-presenting cells (APCs) include B cells, macrophages, and (dendritic/plasma/T) cells.

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You step on something in the yard resulting in a puncture wound that does not bleed freely. Antigens from any microbes that entered the wound will most likely end up in the


A) lymph nodes of the armpit (axilla) .
B) spleen.
C) lymph nodes of the groin (inguinal) .
D) lymph nodes of the neck (cervical) .
E) appendix.

F) A) and D)
G) A) and C)

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Describe the mechanisms of action of antibodies.

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Antibodies act against foreign antigens ...

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Which of the following components of antigen processing is MISMATCHED?


A) endogenous antigen: MHC II
B) exogenous antigen: MHC II
C) phagosome: exogenous antigen
D) endoplasmic reticulum: endogenous antigen
E) endogengous antigen: MHC I

F) C) and D)
G) A) and E)

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A sick child may have influenza or RSV. These virus infections have different treatment options, so the physician requests antibody titer tests. The results are as follows: anti-influenza antibodies are primarily IgM, and anti-RSV antibodies are all IgA and IgG. Which of the following is the most appropriate interpretation?


A) The child has a current RSV infection and was previously exposed to influenza.
B) The child has neither influenza nor RSV.
C) The child currently has influenza and has previously been exposed to RSV.
D) The child has concurrent influenza and RSV infections.
E) The results do not provide sufficient data to draw a conclusion.

F) A) and E)
G) C) and E)

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In what way is the lymphatic system similar to the circulatory system?


A) The composition of lymphatic fluid is similar to that of blood plasma.
B) The same types of cells flow through both systems.
C) The lymphatic system is also a circulatory system.
D) The lymph nodes can contract to push fluid through the system.
E) Fluid flows from larger vessels to capillaries.

F) A) and B)
G) A) and C)

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A

Which of the following function(s) in agglutination?


A) IgE antibodies
B) IgD antibodies
C) IgA antibodies
D) IgG antibodies
E) IgA and IgG antibodies

F) A) and C)
G) C) and D)

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